| Coronary artery disease has spiked by 300 percent among Indians in the past three decades. Iron, an essential element for many important cellular functions in all living organisms, can catalyze the formation of potentially toxic free radicals. Iron is a transition metal that can catalyse toxic redox reactions, and it is involved in many harmful biological reactions and diseases in human body. Excessive iron has been proposed to be a potent risk factor for CHD, especially for AMI. One of the major risk factors of cardiovascular diseases is arteriosclerosis which is secondary to the excess of LDL cholesterol. One-third of ischemic heart diseases in the world are secondary to hypercholesterolemia, and it is estimated that hypercholesterolemia is responsible for 2.6 million (4,5%) deaths in the world
The present study is a prospective nested case-control study of 55 cases of AMI and 60 controls from tertiary care centre in New Delhi.
Mean value of cases and controls Ferritin 211.34±126.1 and 58.05±36.82. The mean and SD of cholesterol 166.16±38.06 and 107.07±15.36, LDL 104.98±41.72 and 54.03±14.78, VLDL 24.11±13.74 and 18.13±2.26 in cases and controls respectively with p<0.0001 and for TG 119.78±69.83 and 92.47±8.57 , with p< 0.007.
In conclusion increased ferritin levels can be considered as the risk factor of CAD in conjuction with other risk factors. TG, LDL-c, VLDL-c, TG and SF levels were raised in patients of AMI and found to be statistically significant. It can be concluded that there exists a relationship in lipid profile and SF with AMI therefore dyslipidemia and raised SF levels are the features of CAD
Keywords: Coronary artery, toxic free radicals, biological reaction
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